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Baclofen is used for treating spasm of skeletal muscles that cause muscle clonus, rigidity, and pain because of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also called striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter within the brain. Neurotransmitters are chemicals that nerves use to convey collectively. GABA released by some nerves causes the game of other nerves to decrease. It is considered that Baclofen, acting like GABA, blocks the adventure of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was authorized by the FDA in November, 1977.

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The usual starting dose of Baclofen for adults is 5 mg thrice daily. Based on the response, the dose could be increased gradually every three days to a maximum of 80 mg/day in several doses.

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Baclofen ought to be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of your reach of youngsters.

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Baclofen could potentially cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure levels, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

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Abrupt discontinuation of oral Baclofen could cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).

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Use of Baclofen with other drugs that also depress the function of nerves can lead to additional lowering of brain function.

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In addition for the probability of depressing brain function, the usage of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could cause muscle weakness.

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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may lead to greater depression of brain function in addition to low blood pressure level.

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As Baclofen can increase blood sugar, doses of antidiabetic drugs ought to be adjusted when Baclofen is taken.

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The utilization of Baclofen by pregnant women hasn't been evaluated.

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Baclofen might be detected inside the breast milk of mothers taking oral Baclofen. No details are on a good Baclofen inside the breast milk of mothers receiving Baclofen intrathecally.

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