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Baclofen is employed for treating spasm of skeletal muscles that can cause muscle clonus, rigidity, and pain on account of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside brain. Neurotransmitters are chemicals that nerves use to communicate together. GABA released by some nerves causes the adventure of other nerves to decrease. It is thought that Baclofen, acting like GABA, blocks the activity of nerves inside the the main brain that controls the contraction and relaxation of skeletal muscle. Baclofen was authorized by the FDA in November, 1977.
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The usual starting dose of Baclofen for adults is 5 mg 3 times daily. Based on the response, the dose may be increased gradually every 3 days to your maximum of 80 mg/day in numerous doses.
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Baclofen needs to be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out from the reach of kids.
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Baclofen could potentially cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
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Abrupt discontinuation of oral Baclofen may cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
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Use of Baclofen with drugs this depress the function of nerves may lead to additional lowering of brain function.
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In addition on the probability of depressing brain function, the usage of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could cause muscle weakness.
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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may result in greater depression of brain function and also low hypertension.
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As Baclofen can increase blood glucose levels, doses of antidiabetic drugs ought to be adjusted when Baclofen is taken.
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The utilization of Baclofen by expectant women will not be evaluated.
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Baclofen might be detected in the breast milk of mothers taking oral Baclofen. No facts are entirely on the presence of Baclofen inside breast milk of mothers receiving Baclofen intrathecally.
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