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Uses

INDICATIONS

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Chloroquine is indicated for the suppressive treatment and for acute attacks of malaria on account of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for your treatments for extraintestinal amebiasis.

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INSTRUCTIONS

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Take chloroquine with meals or milk to lessen stomach upset, unless otherwise directed because of your doctor.

t is very important that you simply take chloroquine only as directed. Do not take really it, don't take it more often, and don't take it for a longer period than a medical expert ordered. To do so may increase the chance of serious side effects.

If you adopt chloroquine to maintain you from getting malaria, keep taking it to the full time of treatment. If you already have malaria, you need to still keep taking chloroquine for your full-time of treatment even if you start to feel good after a couple of days. This will help to your infection completely. If you stop taking chloroquine too quickly, your symptoms may return.

Chloroquine works best when you go on it with a regular schedule. For example, if you are to get it once weekly in order to avoid malaria, it's best to go on the same day per week. Or should you be to consider two doses a day, one dose may be taken with breakfast and also the other while using evening meal. Make sure that you just don't miss any doses. If you might have any queries about this, consult your overall health care professional.

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If you miss a dose of chloroquine, go as quickly as possible. However, whether it is almost time for your next dose, skip the missed dose and get back to your normal dosing schedule. Do not double doses.

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DOSAGE 

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The dosage of chloroquine phosphate is often expressed regarding equivalent chloroquine base. Each 500 mg tablet of ARALEN provides the same in principle as 300 mg chloroquine base. In infants and children the dosage is preferably calculated by bodyweight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on a similar day of weekly.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body weight, but should not exceed the adult dose irrespective of weight.

If circumstances permit, suppressive therapy has to start fourteen days prior to exposure. However, failing this in older adults, an initial double (loading) dose of just one g (= 600 mg base), or in children 10 mg base/kg might be taken in two divided doses, six hours apart. The suppressive therapy should be continued for two months after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of a single g (= 600 mg base) then one more 500 mg (= 300 mg base) after six to eight hours as well as a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents an overall total dose of 2.5 g chloroquine phosphate or 1.5 g base in 3 days.

The dosage for adults of low bodyweight and then for infants and children should be determined as follows:

First dose: 10 mg base per kg (however, not exceeding a single dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding a single dose of 300 mg base).

Third dose: (24 hours after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with an 8-aminoquinoline compound is important.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for just two days, then 500 mg (300 mg base) daily for around 2-3 weeks. Treatment is usually combined having an effective intestinal amebicide.

STORAGE 

Store the medicine in the closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

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Side Effects

Along featuring its needed effects, medicine could cause some negative effects. Although not these unwanted effects may occur, whenever they occur they might need medical attention. When chloroquine is employed for short amounts of time, unwanted side effects are often rare. However, when it can be used for a very long time and/or perhaps in high doses, negative effects will occur and could be serious.

Check with a medical expert immediately if the following unwanted effects occur:
Less common

Blurred vision
alteration of vision
eye pain
loss in vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or any other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any lack of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The unwanted side effects inside Less Common category above could also occur or deteriorate after you stop taking chloroquine.

Some negative effects may occur very often usually do not need medical assistance. These negative effects might have to go away during treatment as the body adjusts to the medicine. Also, your quality of life care professional could possibly be able to share with you ways to stop or reduce many of these side effects. Check with your overall health care professional if these things negative effects continue or are bothersome or if you might have questions about them:


More common

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Diarrhea
difficulty in seeing to read
headache
itching (more established in black patients)
loss of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or within mouth
skin rash

Other unwanted side effects unlisted can also occur in some patients. If you notice every other effects, seek advice from your medical practioner.

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Precautions

If you may be taking chloroquine for a very long time, it is vital that your doctor check you at regular visits for any blood problems or muscle weakness that could possibly be caused by chloroquine. In addition, check with your doctor immediately if blurred vision, difficulty in reading, or any other alteration of vision occurs during or after treatment. Your doctor may wish one to have up your eyes checked by an ophthalmologist (eye doctor).

If your symptoms tend not to improve inside a week or if they become worse, seek advice from your medical professional.

Make sure you are aware how you reply to chloroquine when you drive, use machines, or a single thing else that is dangerous should you be not able to see well.

Chloroquine could potentially cause blurred vision, difficulty in reading, and other change in vision. It might also cause many people to become lightheaded.

If these reactions are especially bothersome, talk with a medical expert.

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Certain medicines should not be used at or around the time of eating food or eating some types of food since interactions may occur. Using alcohol or tobacco with certain medicines could also cause interactions to occur. Discuss using your medical practioner the use of your medicine with food, alcohol, or tobacco.

There are not any adequate and well-controlled studies evaluating the protection and efficacy of chloroquine in pregnant women. Usage of chloroquine in pregnancy ought to be avoided except inside suppression or treatment of malaria when inside judgment of the physician the power outweighs the opportunity risk to the fetus.

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