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See also Warning section.

This medicine is used to take care of mental/mood that is certain (schizophrenia, schizoaffective disorders). Clozapine is a psychiatric medication (anti-psychotic type) that actually works by helping to restore the balance of particular normal substances (neurotransmitters) into the brain.

Clozapine decreases hallucinations and aids in preventing committing suicide in those who are most likely to test to harm themselves. It helps one to clearly think more and favorably about your self, feel less nervous, and indulge in everyday life.

How to use Clozaril

If you are utilizing the liquid form of the medication, read the Patient Suggestions Leaflet if available from your pharmacist before you start taking clozapine and any time you get a refill. If you have any relevant questions, pose a question to your doctor or pharmacist.

Just take this medicine by mouth with or without food, as directed by your doctor. If you're taking the tablets that dissolve in the mouth, carefully remove each tablet from the blister pack immediately before taking your dose. Allow the tablets to dissolve on your tongue and swallow. There is no need to take the dissolving tablets with water. Discard any dissolving tablets that have been formerly confronted with air due to opened/damaged packaging. Do not conserve them for your next dose.

If you are using the form that is liquid of medication, shake the bottle well for 10 seconds before each use. Carefully measure the dose using a measuring device/spoon that is special. Do not use a household spoon because may very well not get the correct dose.

You should start taking this drug at a low dose, increasing your dose slowly, to lessen side effects such as dizziness, drowsiness and seizures. Follow your doctor's instructions exactly. Your dosage is based on your medical condition and response to therapy. Since clozapine can cause a decrease in white blood cells, you shall need certainly to get blood tests done regularly as directed. Be sure to keep all appointments of these laboratory tests. (See also Notes section.)

You were on (see Missed Dose section) if you miss your doses for longer than a day or two, consult your doctor for a new schedule to get back to the dose. Use this medication regularly in order to get the benefit that is most from this. To help you keep in mind, make use of it at the same time(s) each day.

Do not stop taking clozapine without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Also, you might experience symptoms such as severe sweating, headache, nausea, vomiting, and diarrhea. To avoid these symptoms while you might be stopping treatment with this drug, your physician may lower your dose slowly. Consult with your doctor or pharmacist for more details. Report any new or worsening symptoms right away.

It might take several weeks prior to the full benefit of this drug takes effect. Inform your physician if your condition persists or worsens.

Side Effects

See also Warning section.

Drooling, drowsiness, dizziness, headache, shaking (tremor), vision problems (e.g., blurred vision), weight gain, and constipation may occur. Many of these effects (especially drowsiness) lessen as your body gets used to the medication. If any of these effects persist or worsen, contact your doctor or pharmacist quickly.

To stop constipation, maintain a meal plan adequate in fiber, drink plenty of water, and workout. If you become constipated while using the this drug, consult your pharmacist for help in selecting a laxative (age.g., stimulant-type with stool softener).

Understand that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of adverse effects. Many people using this medication do not have serious adverse effects.

This medicine may make your blood rarely sugar level rise, which can cause or worsen diabetes. Rarely, very serious conditions such as diabetic coma may occur. Tell your medical practitioner immediately if you develop symptoms of high blood glucose, such as increased thirst and urination. If you already have diabetes, be sure to always check your blood sugars regularly. Your doctor might have to adjust your diabetes medication, exercise program, or diet.

This drug might also cause significant weight gain and a rise in your cholesterol (or triglyceride) levels. These effects, along side diabetic issues, may increase your risk for developing heart condition. Talk about the dangers and advantages of therapy with your doctor.

Tell your doctor right away when you have any side that is serious, including: facial/muscle twitching, seizures, uncontrollable movements.

Get help that is medical away if you have really serious side effects, including: severe dizziness, fainting, mental/mood changes, difficulty breathing with exercise, sudden weakness, pain/redness/swelling of the arms/legs, persistent nausea/vomiting, stomach/abdominal pain, yellowing of eyes/skin.

This medication may hardly ever cause a really condition that is serious neuroleptic malignant syndrome (NMS). Get medical help right away if you have associated with the following symptoms: temperature, muscle tissue stiffness/pain/tenderness/weakness, severe tiredness, serious confusion, sweating, fast/irregular heartbeat, dark urine, change in the number of urine.

A very serious reaction that is allergic this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious reaction that is allergic consist of: rash, itching/swelling (especially of the face/tongue/throat), serious dizziness, trouble breathing.

This isn't a complete list of possible adverse effects. If you notice other effects not listed above, contact your pharmacist or doctor.

In the US -

Call your doctor for medical advice about side impacts. You may report side effects to Food And Drug Administration at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about adverse effects. You might report effects that are side Health Canada at 1-866-234-2345.


See also Warning and Side Effects parts.

Before using clozapine, inform your physician or pharmacist if you have any other allergies if you are allergic to it or. This product may contain ingredients that are inactive which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your medical practitioner or pharmacist your medical history, particularly of: history of bloodstream disorders (such as for example leukemia, low blood that is white count), bowel problems (such as paralytic ileus, cranky bowel problem ), difficulty in breathing, diabetes/family history of diabetes, high cholesterol/triglyceride levels, glaucoma, heart problems, renal problems, liver problems, obesity/family history of obesity, seizures, difficulty urinating (such as prostate problems).

Clozapine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as serious dizziness, fainting) that require medical attention right away.

The risk of QT prolongation may be increased if you have particular medical conditions or are taking other drugs that may affect the center rhythm. Before making use of clozapine, tell your medical professional or pharmacist of all the drugs you take and when you have any of the following conditions: certain heart dilemmas (heart failure, slow heartbeat, QT prolongation into the EKG), genealogy and family history of certain heart disease (QT prolongation in the EKG, unexpected cardiac death).

Lower levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you have conditions such as severe sweating, diarrhea, or vomiting if you use certain drugs (such as diuretics/"water pills") or. Speak to your doctor about using clozapine safely.

This drug can make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

Tell your physician if you are a descendent of Ashkenazi Jews because you may be at a higher risk for a drop in your white blood cells.

Before having surgery, tell your doctor or dentist that you are by using this medicine.

Liquid products or dissolving tablets may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised you to limit/avoid these substances in your diet if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires. Ask your pharmacist or doctor about making use of this product safely.

Older grownups may be more responsive to the relative side aftereffects of this drug, especially constipation, dizziness, and QT prolongation (see above). Dizziness can increase the danger of falling.

During maternity, this medicine should be used only when demonstrably needed. Babies born to mothers who have used this drug over the past 3 months of pregnancy may rarely develop signs muscle that is including or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor immediately.

Since untreated mental/mood issues (such as for instance schizophrenia, schizoaffective problems) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This medication may pass into breast milk and have effects that are undesirable a nursing infant. Breast feeding is not recommended while taking clozapine. Consult your doctor before breast-feeding.

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