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Uses

INDICATIONS

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Indinavir is surely an antiviral medication in a very band of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body. It is utilized to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is just not a cure for HIV or AIDS.

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INSTRUCTIONS

Take indinavir exactly as it absolutely was prescribed for you. Do not go ahead and take medication in larger amounts, or get it for longer than recommended from your doctor. Follow the directions in your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your medical professional or pharmacist in case you have questions.
Take indinavir with a full glass (8 ounces) of water or skim milk. You might also drink juice, coffee, or tea with this medication. Drink a minimum of 6 associated with water every day to prevent kidney stones if you are taking indinavir. Indinavir needs to be taken on a clear stomach, no less than 60 minutes before or 2 hours from a meal.

If you prefer to go ahead and take medication with food, eat just a light meal, for example dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is vital to utilize indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of drugs completely.

To be certain this medication is helping your complaint, your blood must be tested often. Your liver function may also have to be tested. Do not miss any scheduled visits to your physician.

HIV/AIDS is normally treated using a combination of different drugs. To best treat your complaint, utilise all of your medications as directed from your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not make positive changes to doses or medication schedule without advice from a medical expert. Every person with HIV or AIDS should remain beneath the proper care of a health care provider.

Take the missed dose once you remember and take your following dose in the regularly scheduled time. If you are greater than 120 minutes late in taking your indinavir, skip the missed dose and consider the next regularly scheduled dose. Do not take extra medicine to produce inside the missed dose.

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DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.

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Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis ought to be initiated as quickly as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is amongst the alternative regimens suited to nonoccupational postexposure HIV prophylaxis.

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Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy has to start promptly, preferably within 1 to a couple of hours postexposure. The exact use of therapy varies based on the institution's protocol.

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Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.

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Dose Adjustments
Consider decreasing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is given concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence on the prescribed dose is essential. Patients shouldn't affect the dose or discontinue therapy without consulting their physician.

Adequate hydration (1.5 liters/day) is important during therapy to relieve the chance of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation may be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

Store indinavir at room temperature far from moisture and warmth. Keep the capsules inside their original container, combined with packet of moisture-absorbing preservative that includes indinavir capsules.

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Side Effects

Get emergency medical help when you have some of these signs and symptoms of a hypersensitive reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call your medical professional simultaneously in case you have any of these serious negative effects:

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Less serious unwanted effects might include:

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This is just not a complete list of unwanted effects and others may occur. Tell your physician about any unusual or bothersome unwanted effect.

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Precautions

Do not take this medication if you're allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines for example ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs could cause life-threatening unwanted effects if you are using them while you are taking indinavir.

Before taking indinavir, tell your medical professional if you're allergic to any drugs, or if you have:

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If you have some of these conditions, you might need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication could possibly be harmful to an baby. Tell your medical professional if you are pregnant or prefer to become pregnant during treatment. HIV may be passed on the baby when the mother isn't properly treated while pregnant. Take all of one's HIV medicines as directed to moderate your infection if you are pregnant.

Your name may must be from an antiviral pregnancy registry once you start using this medication.
You should not breast-feed when you are using indinavir. Women with HIV or AIDS should not breast-feed whatsoever. Even if your child is born without HIV, you might still pass herpes on the baby within your breast milk.

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