Methotrexate is used to treat certain forms of cancer or even to control psoriasis that is severe rheumatoid arthritis that has not responded to other treatments. It may also be used to control rheumatoid arthritis that is juvenile. Methotrexate belongs to a class of drugs called antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.
Early remedy for arthritis rheumatoid with more aggressive treatment such as for instance methotrexate helps to reduce further joint harm and to preserve joint function.
OTHER USES: This section contains uses of this medication that are not listed in the approved labeling that is professional the drug but that will be prescribed by the health care pro. Utilize this drug for a condition which is placed in this section as long as it offers been so prescribed by your medical care professional.
This medicine could also be used for lupus and arthritis that is psoriatic.
Read the Patient Information Leaflet if available from your pharmacist before you start taking methotrexate and each time you get a refill. If you have any relevant questions, pose a question to your doctor or pharmacist.
Methotrexate is a strong medication. The dosage and how often you take this medication are based on your condition that is medical and to therapy. There are many dosing that is different for this medication (especially for cancer therapy). Therefore, it is crucial that you follow your physician's directions carefully. Take this medication by mouth as directed by your doctor.
For the treating psoriasis or rheumatoid arthritis, take this medicine by mouth as directed by your physician, usually when a week. It may take around several months before you get the benefit that is full of medication.
Do not increase your dose or use this drug more often or for longer than prescribed. Your condition shall not improve any faster, along with your risk of unwanted effects will increase.
Since this drug can be absorbed through your skin and lung area that can harm an unborn baby, ladies who are pregnant or who may get pregnant should not handle this medicine or breathe the dust from the tablets.
Drink plenty of fluids while taking this medication unless your physician tells you otherwise. Doing this helps your kidneys to get rid of the medication from your body and avoid a few of the relative adverse effects.
See section that is also warning.
Nausea, nausea, stomach pain, drowsiness, or dizziness might occur. If any of these effects persist or worsen, tell your doctor or pharmacist immediately.
Temporary hair loss may occur. Normal hair regrowth should return after treatment has ended.
Remember your physician has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have adverse that is serious.
Tell your doctor appropriate away in the event that you have adverse that is serious, including: mouth sores, diarrhea, signs of anemia (such as unusual tiredness, pale skin), indications of liver problems (such as for example dark urine, persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin), easy bruising/bleeding, black stools, enlarged glands/lymph nodes, bone tissue pain, unusual pain and discoloration of skin, change in the total amount of urine, dry coughing, muscle weakness.
Get medical help right away if you have any really serious side effects, including: weakness on one part of this body, throat stiffness, serious hassle, eyesight changes, irregular heartbeat, mental/mood changes, seizures.
This medication might lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent throat that is sore coughing).
This medication can impact sperm production, a result that may reduce fertility that is male. Consult your doctor for lots more details.
A very serious allergic reaction to this drug is rare. However, get help that is medical away in the event that you notice any observeable symptoms of a serious allergic reaction, including: rash, itching/swelling (especially associated with the face/tongue/throat), severe dizziness, difficulty breathing.
This is not a complete list of possible adverse effects. If you notice other effects not listed above, contact your pharmacist or doctor.
Into the US -
Phone your physician for medical advice about side-effects. You may possibly report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about unwanted effects. You may report side effects to Health Canada at 1-866-234-2345.
See also Warning section.
Before taking methotrexate, tell your physician or pharmacist if you have any other allergies if you are allergic to it; or. This product may contain ingredients that are inactive that may cause allergic reactions or other issues. Speak to your pharmacist for more details.
Before using this medication, tell your physician or pharmacist your health background, specially of: liver infection, renal illness, lung disease (such as for example pulmonary fibrosis), liquor usage, suppressed immune system, blood cell/bone marrow disorders, stomach/intestinal diseases (such as for example peptic ulcer, ulcerative colitis), any active illness (including chickenpox or current exposure to it), folic acid deficiency.
Methotrexate can make you prone to get infections or may worsen any current infections. Consequently, clean your hands well to stop the spread of infection. Avoid contact with individuals who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor for those who have been confronted with an infection or for more details.
Don't have immunizations/vaccinations without the consent of your doctor. Avoid contact with individuals who have recently received vaccines that are livesuch as for instance flu vaccine inhaled through the nose).
To lower the possibility of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as for example contact sports.
This drug might make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness you can perform such activities safely until you are sure. Avoid alcoholic beverages.
Before having surgery, tell your physician or dentist about all the merchandise you use (including prescription drugs, nonprescription medications, and herbal products).
This medication might make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear clothing that is protective outdoors.
Methotrexate must not be utilized during pregnancy. It would likely harm an unborn baby. It is important to prevent pregnancy during and after treatment with methotrexate. Therefore, males and females must use reliable forms of birth control (such as condoms, birth control pills) during treatment. Males should continue to use birth control for at least 3 months after the final end of treatment. Females should continue to use birth control for at minimum 1 menstrual cycle after the end of treatment. If you become pregnant or think you may be pregnant, tell your doctor right away.
Since this drug can be absorbed through the epidermis and lungs and may harm an unborn baby, women who're pregnant or who may get pregnant should not handle this medication or inhale the dust from the tablets.
Methotrexate passes into breast milk and may harm a medical infant. Therefore, breast-feeding when using this drug is not recommended. Consult with your doctor before breast-feeding.
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