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Generic Motilium is used to supress nausea and vomiting, and works primarily by blocking dopamine receptors found in the upper end of the system that is digestive. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the way that is wrong the stomach therefore prevents reflux (regurgitation of the stomach articles right back into the foodpipe).

Side Results

Unwanted effects include:



Since domperidone is highly metabolised in the liver, domperidone should be utilized with caution in patients with hepatic disability (and in the elderly).

Domperidone should really be used with caution in patients with renal disability or in those at risk of water retention. In patients with severe renal insufficiency (serum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should once be reduced to or twice daily, with regards to the severity of impairment, and the dose may require to be paid down. Patients on prolonged therapy should regularly be reviewed.

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