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Promethazine is at a small grouping of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing those things of chemicals within your brain. Promethazine also acts as an antihistamine. It blocks the effects in the naturally occurring chemical histamine with your body.

Promethazine is employed to help remedy allergic reactions including itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used like a sedative or sleep aid.

Promethazine just isn't to be used for the signs of asthma, pneumonia, and other lower respiratory tract infections.

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Take promethazine exactly as prescribed through your doctor. Do not take it in larger amounts and longer than recommended. Follow the directions on the prescription label.

Your doctor may occasionally alter your dose to make sure you acquire the best results from this medication.

Promethazine may be taken with or without food or milk.

Measure liquid medicine using a marked measuring spoon or medicine cup, not with a regular table spoon. If you usually do not use a dose-measuring device, ask your pharmacist for starters.

Call your physician should your symptoms usually do not improve, or if they become worse while taking promethazine.

This medication may cause you to have unusual results with certain lab tests. Tell any doctor who treats you that you will be using promethazine.

Seek emergency medical assistance if you think maybe you've got used which is not this medicine. Overdose symptoms might include severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting.


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Take becoming prescribed through your doctor.


Store promethazine at room temperature from moisture, heat, and light-weight.


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Side Effects

Get emergency medical help if you've all of these warning signs of a hypersensitive reaction: hives; lack of breath; swelling of your respective face, lips, tongue, or throat. Stop using promethazine and call a medical expert at once if you've got all of these serious side effects:

twitching, or uncontrollable movements of the eyes, lips, tongue, face, arms, or legs;

tremor (uncontrolled shaking), drooling, trouble swallowing, difficulties with balance or walking;

feeling restless, jittery, or agitated;

high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;

feeling just like you might pass out;

seizure (convulsions);

pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;

decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;

hallucinations, agitation;

nausea and stomach pain, skin rash, and jaundice (yellowing from the skin or eyes);

urinating less than usual or not in any way;

joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy pores and skin; or

slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious promethazine unwanted side effects might include:

dizziness, drowsiness, anxiety;

blurred vision, dry mouth, stuffy nose;

ringing in your ears;

weight gain, swelling within your hands or feet;

impotence, trouble through an orgasm; or


This is just not a complete set of unwanted side effects yet others may occur. Tell your physician about any unusual or bothersome unwanted effect.

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Stop using promethazine and call your doctor at the same time if you've twitching or uncontrollable movements of one's eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Promethazine could cause side effects that will impair your opinions or reactions. Be careful in the event you drive or do anything whatsoever that will require you to be awake and alert. Avoid having a drink, which could increase some from the unwanted effects of promethazine. There are many other medicines that will talk with promethazine. Tell your doctor about every one of the prescription and over-the-counter medications you employ. This includes vitamins, minerals, herbal products, and prescriptions given by other doctors. Do not start using a new medication without telling a medical expert. Keep a list together with you of all the medicines you have and show this list to the doctor or any other healthcare provider who treats you.

Important safety information:

Promethazine shouldn't be provided to a young child younger than 2 years old. Promethazine may cause severe breathing problems or death in a kid younger than 2. Carefully follow your doctor's instructions when giving this medicine to a youngster of any age. Do not use medicines if you've severe asthma, emphysema, and other breathing problem, or in case you are allergic to promethazine or other phenothiazines for example chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), thioridazine (Mellaril), or trifluoperazine (Stelazine).

If you've certain conditions, you need a dose adjustment or special tests to soundly use medicines. Before you take promethazine, tell your doctor if you've:

a good seizures;

heart disease or high blood pressure levels;

liver or kidney disease;

severe asthma, emphysema, chronic obstructive pulmonary disease (COPD) or another breathing problem;

sleep apnea (breathing stops while asleep);


a stomach ulcer or digestive obstruction;

bone marrow depression;

adrenal gland tumor (pheochromocytoma);

enlarged prostate or difficulty with urination;

low numbers of calcium inside your blood (hypocalcemia); or

if you've ever stood a serious side-effect while using promethazine or other phenothiazine.

FDA pregnancy category C. It is not known whether promethazine is harmful for an unborn baby. Tell your physician in case you are pregnant or want to get pregnant during treatment. It is just not known whether promethazine passes into breast milk or if it may harm a nursing baby. Do not use medicines without telling your physician in the event you are breast-feeding a child. Older adults could possibly be more prone to have unwanted side effects from promethazine.

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