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Promethazine is at a gaggle of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing those things of chemicals with your brain. Promethazine also acts being an antihistamine. It blocks the effects in the naturally occurring chemical histamine in your body.

Promethazine is used to deal with allergy symptoms including itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used being a sedative or sleep aid.

Promethazine isn't for use in treating the signs of asthma, pneumonia, or another lower respiratory tract infections.


Take promethazine just as prescribed because of your doctor. Do not take it in larger amounts or longer than recommended. Follow the directions on the prescription label.

Your doctor may occasionally change your dose to ensure that you acquire the best results from medicines.

Promethazine might be taken with or without food or milk.

Measure liquid medicine using a marked measuring spoon or medicine cup, not with a regular table spoon. If you don't have a very dose-measuring device, ask your friendly phamacist for starters.

Call your medical professional should your symptoms usually do not improve, or if they deteriorate while taking promethazine.

This medication might cause one to have unusual results with certain medical tests. Tell any doctor who treats you that you're using promethazine.

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Seek emergency medical help if you think you have used which is not this medicine. Overdose symptoms can include severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting.


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Take it as being prescribed through your doctor.

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Store promethazine at room temperature faraway from moisture, heat, and light-weight.

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Side Effects

Get emergency medical help if you have some of these signs and symptoms of a hypersensitivity: hives; lack of breath; swelling of one's face, lips, tongue, or throat. Stop using promethazine and call your medical professional at the same time if you've got all of these serious negative effects:

twitching, or uncontrollable movements of one's eyes, lips, tongue, face, arms, or legs;

tremor (uncontrolled shaking), drooling, trouble swallowing, issues with balance or walking;

feeling restless, jittery, or agitated;

high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;

feeling as you might faint;

seizure (convulsions);

pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;

decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;

hallucinations, agitation;

nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);

urinating lower than usual or otherwise not whatsoever;

joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy complexion; or

slow pulse rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious promethazine unwanted effects might include:

dizziness, drowsiness, anxiety;

blurred vision, dry mouth, stuffy nose;

ringing in your ears;

weight gain, swelling within your hands or feet;

impotence, trouble using an orgasm; or


This is not a complete report on unwanted side effects while others may occur. Tell a medical expert about any unusual or bothersome unwanted effect.


Stop using promethazine and call your medical professional at the same time if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous unwanted side effects. Promethazine might cause negative effects that may impair your opinions or reactions. Be careful should you drive or a single thing that will need one to be awake and alert. Avoid alcohol consumption, which could increase some from the unwanted side effects of promethazine. There are many other medicines that will talk with promethazine. Tell your medical professional about all of the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and prescriptions given by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of each of the medicines you employ and show this list to the doctor or any other doctor who treats you.

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Important safety information:

Promethazine should not be provided to a child younger than 2 years old. Promethazine could cause severe breathing problems or death in a kid younger than 2. Carefully follow your doctor's instructions when giving this medicine to a youngster of any age. Do not use prescription drugs if you have severe asthma, emphysema, or another breathing problem, or if you are allergic to promethazine or any other phenothiazines like chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), thioridazine (Mellaril), or trifluoperazine (Stelazine).

If you've certain conditions, you may need a dose adjustment or special tests to safely use medicines. Before you take promethazine, tell your medical professional if you have:

a good reputation for seizures;

heart disease or blood pressure;

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liver or kidney disease;

severe asthma, emphysema, chronic obstructive pulmonary disease (COPD) or any other breathing problem;

sleep apnea (breathing stops while asleep);


a stomach ulcer or digestive obstruction;

bone marrow depression;

adrenal gland tumor (pheochromocytoma);

enlarged prostate or issues with urination;

low degrees of calcium in your blood (hypocalcemia); or

if you might have ever a serious unwanted effect when using promethazine or another phenothiazine.

FDA pregnancy category C. It is not known whether promethazine is harmful with an baby. Tell your physician should you are pregnant or intend to get pregnant during treatment. It is just not known whether promethazine passes into breast milk or if it could possibly harm a nursing baby. Do not use prescription drugs without telling your doctor should you are breast-feeding a child. Older adults could possibly be more likely to have negative effects from promethazine.

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