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Precautions

Do NOT use Vytorin if:

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• you're allergic to any ingredient in Vytorin

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• you might have liver problems or ongoing abnormal liver function test results

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• you consider another medicine which has simvastatin or ezetimibe

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• you consider an HIV protease inhibitor (eg, nelfinavir, lopinavir, ritonavir), itraconazole, ketoconazole, a macrolide or ketolide antibiotic (eg, clarithromycin, erythromycin, troleandomycin), mibefradil, or nefazodone

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• you might be pregnant or breast-feeding.

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Contact your physician or health care provider right away if these connect with you.

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Some medical conditions may talk with Vytorin. Tell your doctor or pharmacist for those who have any medical ailments, in particular when any in the following affect you:

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• should you be pregnant, likely to get pregnant, or are breast-feeding

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• in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• when you have allergies to medicines, foods, or another substances

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• for those who have kidney problems, muscle problems, or possibly a family history of muscle problems; low blood pressure; uncontrolled seizures; or serious metabolic, endocrine, or electrolyte problems

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Some medicines may communicate with Vytorin. Tell your physician should you be taking another medicines, especially any of the following:

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• Amiodarone, angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, itraconazole, ketoconazole), cyclosporine, danazol, delavirdine, diltiazem, fibrates (eg, clofibrate, fenofibrate), fluconazole, gemfibrozil, HIV protease inhibitors (eg, ritonavir), imatinib, macrolide antibiotics (eg, erythromycin), macrolide immunosuppressives (eg, tacrolimus), mibefradil, nefazodone, niacin, nicotinic acid, streptogramins, telithromycin, verapamil, or voriconazole because negative effects, for example muscle pain, may occur

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• Bosentan, carbamazepine, cholestyramine, hydantoins (eg, phenytoin), rifampin, or St. John's wort because they may decrease Vytorin's effectiveness

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• Anticoagulants (eg, warfarin) as the likelihood of their side effects may be increased by Vytorin.

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This will not be a whole report on all interactions that may occur. Ask your doctor if Vytorin may interact with other medicines that you just take. Check together with your doctor before you begin, stop, or affect the dose of any medicine.

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Important safety information:

• Vytorin may cause dizziness, drowsiness, or modifications in vision. These effects could possibly be worse if you go with alcohol or certain medicines. Use Vytorin with caution. Do not drive or perform other possible unsafe tasks and soon you recognize how you reply to it.

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• Proper dental care is important when you are taking Vytorin. Brush and floss your teeth and check out the dentist regularly.

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• Vytorin may harm your liver. Your risk could possibly be greater in the event you consume alcohol if you are using Vytorin. Talk to your doctor prior to taking Vytorin or any other fever reducers if you drink greater than 3 drinks with alcohol daily.

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• Vytorin may cause trouble for your muscles, particularly when taken at higher doses or when taken with certain other medicines. Contact your medical professional straight away should you experience muscle pain, tenderness, or weakness, especially with a fever.

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• Lab tests, including blood cholesterol, liver function tests, or muscle tests, may be performed whilst you use Vytorin. These tests could possibly be used to monitor your trouble or search for unwanted side effects. Be sure to keep all doctor and lab appointments.

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• Vytorin ought to be used in combination with careful attention in children younger decade; safety and effectiveness during these children have not been confirmed.

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• Pregnancy and breast-feeding: Do not use Vytorin in case you are pregnant. Avoid pregnancy while you're taking it. If you think you could be pregnant, contact your medical professional without delay. It is not known if Vytorin can be found in breast milk. Do not breastfeed while taking Vytorin.

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