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Precautions

Do NOT use Vytorin if:

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• you might be allergic to your ingredient in Vytorin

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• you've liver problems or ongoing abnormal liver function test results

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• you take another medicine which has simvastatin or ezetimibe

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• you consider an HIV protease inhibitor (eg, nelfinavir, lopinavir, ritonavir), itraconazole, ketoconazole, a macrolide or ketolide antibiotic (eg, clarithromycin, erythromycin, troleandomycin), mibefradil, or nefazodone

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Contact a medical expert or doctor straight away if all of these affect you.

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Some health concerns may communicate with Vytorin. Tell your physician or pharmacist for those who have any health conditions, particularly when any from the following affect you:

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• should you be pregnant, intending to get pregnant, or are breast-feeding

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• when you have allergies to medicines, foods, and other substances

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• if you are a woman of childbearing age
• if you have kidney problems, muscle problems, or even a ancestors and family history of muscle problems; low blood pressure level; uncontrolled seizures; or serious metabolic, endocrine, or electrolyte problems

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• in case you are scheduled for major surgery, have recently had a major trauma, or have a very severe infection or good reputation for alcohol abuse

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Some medicines may talk with Vytorin. Tell your health care provider if you're taking some other medicines, especially any from the following:

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• Amiodarone, angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, itraconazole, ketoconazole), cyclosporine, danazol, delavirdine, diltiazem, fibrates (eg, clofibrate, fenofibrate), fluconazole, gemfibrozil, HIV protease inhibitors (eg, ritonavir), imatinib, macrolide antibiotics (eg, erythromycin), macrolide immunosuppressives (eg, tacrolimus), mibefradil, nefazodone, niacin, nicotinic acid, streptogramins, telithromycin, verapamil, or voriconazole because negative effects, including muscle pain, may occur

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• Bosentan, carbamazepine, cholestyramine, hydantoins (eg, phenytoin), rifampin, or St. John's wort given that they may decrease Vytorin's effectiveness

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• Anticoagulants (eg, warfarin) because the risk of their side effects could be increased by Vytorin.

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This may not be a complete listing of all interactions that may occur. Ask your health care provider if Vytorin may interact with other medicines which you take. Check with your physician before starting, stop, or alter the dose from a medicine.

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Important safety information:

• Vytorin could cause dizziness, drowsiness, or alterations in vision. These effects could be worse should you go with alcohol or certain medicines. Use Vytorin with caution. Do not drive or perform other possible unsafe tasks before you recognize how you react to it.

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• Proper dental treatments is vital while you're taking Vytorin. Brush and floss your teeth and look at the dentist regularly.

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• Vytorin may harm your liver. Your risk could be greater if you are drinking alcoholic beverages when you are using Vytorin. Talk to your medical professional before you take Vytorin or another fever reducers should you drink over 3 drinks with alcohol every day.

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• Vytorin might cause damage to your muscle mass, particularly if taken at higher doses or when taken with certain other medicines. Contact your medical professional immediately if you experience muscle pain, tenderness, or weakness, especially with temperature.

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• Some patients taking Vytorin have reported poor memory or sleep problems. If you experience these effects, check with a medical expert.

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• Lab tests, including blood blood choleseterol levels, liver function tests, or muscle tests, may be performed when you use Vytorin. These tests could possibly be used to monitor your condition or pay attention to side effects. Be sure to keep all doctor and lab appointments.

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• Vytorin should be used in combination with warning in children younger a decade; safety and effectiveness over these children have not been confirmed.

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• Pregnancy and breast-feeding: Do not use Vytorin if you are pregnant. Avoid getting pregnant when you are taking it. If you think you could possibly be pregnant, contact a medical expert without delay. It is not known if Vytorin is located in breast milk. Do not breastfeed while taking Vytorin.

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